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Public release date: 31-Jan-2013[ | E-mail |
Share ] Contact: Matthew Lopez
mlopez@plos.org
415-568-3174
Public Library of Science
Fight against river blindness is successful and inexpensive
A relatively inexpensive program set up to combat river blindness, an infectious disease, has resulted in major health improvements in Africa, shows a study conducted by Erasmus University Medical Center researchers. The study, due to be published January 31 in PLOS Neglected Tropical Diseases, shows that US$250 million helped cure or prevent blindness, skin disease, severe itching, and other symptoms in millions of people. In collaboration with the Management of the African Programme for Onchocerciasis Control (APOC), the researchers calculated the health impact of APOC.
Onchocerciasis, also known as river blindness, is an infectious parasitic disease transmitted by flies that live near fast-flowing rivers. The worm that causes the disease lives in subcutaneous nodules. The bite of the fly passes the worm's larvae from human to human. During their lifetime, people in endemic regions often contract several infections, which accumulate and can lead to blindness. Infected people may suffer from severe itching, leading to insomnia and inability to concentrate. This makes working or going to school difficult. 'This means people are less able to provide for themselves, especially in developing countries,' says Erasmus MC researcher Luc Coffeng. 'It is for a reason that in images of river blindness you often see a blind person moving around holding the end of a stick accompanied by a child holding the other end.'
In 1995, the WHO launched the African Programme for Onchocerciasis Control (APOC) to combat river blindness. APOC has geographically mapped the disease, and has started annual mass treatment with the drug ivermectin in sixteen African countries. Ivermectin kills the larvae in the human and thus prevents transmission of the infection and development of irreversible symptoms, such as blindness. Manufacturer Merck helps by providing ivermectin for as long as needed, free of charge. APOC distributes the drug in an efficient and inexpensive manner through a community-directed approach. Specially trained volunteers operate at the local level; they find out which people are eligible for treatment, and ensure that these people get the drug. This saves time for health professionals, and makes it easier to continue mass treatment in situations of political instability.
In fifteen years' time, APOC has had a major health impact at relatively low cost, according to the researchers. The percentage of people infected with the parasite decreased from 45 to 31 percent among a population of 104 million people. 'Blindness and visual impairment now occur much less frequently in the APOC countries. And the percentage of people suffering from severe itching decreased from 14 to 6 percent,' said Coffeng. The researchers express the impact of the programme in terms of years of healthy life gained: 'This metric expresses our preference for people to live their life in good health rather than in disease. For instance, for every year lived in blindness, we consider 0.6 years of healthy life lost.' The program has already saved a total of eight million healthy years of life, at a cost of about US$250 million. 'Peanuts compared to what we in the Western world are spending on healthcare,' commented Coffeng. 'APOC costs 30 dollars for every year of healthy life gained, while in the Western world we are willing to spend tens of thousands of dollars to achieve this.'
The fight against river blindness is not yet over. The percentage of people carrying infection is expected to decline further, to about 18% in 2015. 'APOC has made tremendous efforts to implement mass treatment in all countries in need. The last countries joined the program only in 2010. Treatment must continue for many years, because the drugs only kill the larvae and not the adult worms, which can live inside humans for over 10 years,' observes Coffeng. In other words: it is very important that APOC continues its activities, which requires continued support from drug-donating pharmaceutical companies and donor countries, and continued commitment from national governments of the African countries in question and local volunteers. 'The eventual goal of APOC is to completely eradicate river blindness, and this seems to be possible if all stakeholders commit to that goal.'
###
FINANCIAL DISCLOSURE: This study was funded by the World Health Organization / African Programme for Onchocerciasis Control (APOC/CEV/322/07). H.G.M. Zour, K.B. Agblewonu, M. Noma, G. Fobi, U.V. Amazigo are or have been employees of the African Programme for Onchocerciasis Control (APOC), World Health Organization. The authors state that their employment has not caused any conflict of interest in any of the following: study design, data collection, data analysis, interpretation, decision to publish.
COMPETING INTERESTS: The International Bank for Reconstruction and Development/World Bank serves as Fiscal Agent to WHO APOC through its fiduciary oversight of the APOC Trust Fund and contributed to this paper through its work with the APOC secretariat in the maintenance of accurate financial records. The findings, interpretations and conclusions expressed in this paper do not necessarily reflect the views of the World Bank. Furthermore, H.G.M. Zour, K.B. Agblewonu, M. Noma, G. Fobi, U.V. Amazigo are or have been employees of the African Programme for Onchocerciasis Control (APOC), World Health Organization. The authors state that their employment has not caused any conflict of interest in any of the following: study design, data collection, data analysis, interpretation, decision to publish.
CITATION: Coffeng LE, Stolk WA, Zoure HGM, Veerman JL, Agblewonu KB, et al. (2013) African Programme for Onchocerciasis Control 1995: Model-Estimated Health Impact and Cost. PLoS Negl Trop Dis 7(1): e2032. doi:10.1371/journal.pntd.0002032
CONTACT:
Luc Coffeng
l.coffeng@erasmusmc.nl
Disclaimer
This press release refers to an article in PLOS Neglected Tropical Diseases. The release is provided by the article authors. Any opinions expressed in these releases or articles are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.
Media Permissions
PLOS Journals publish under a Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits free reuse of all materials published with the article, so long as the work is cited (e.g., Kaltenbach LS et al. (2007) Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration. PLoS Genet 3(5): e82. doi:10.1371/journal.pgen.0030082). No prior permission is required from the authors or publisher. For queries about the license, please contact the relative journal contact indicated here: http://www.plos.org/journals/embargopolicy.php
About Erasmus University Medical Center, Rotterdam
Erasmus MC is the largest and most authoritative scientific academic medical center in the Netherlands. Almost 13,000 staff members work within the core tasks of patient care, education, and scientific research on the continuous improvement and enforcement of individual patient care and social healthcare. They develop high-level knowledge, pass this on to future professionals, and apply it in everyday patient care. Over the next five years, Erasmus MC wants to grow into one of the best medical institutes in the world. Erasmus MC is part of the Dutch Federation of University Medical Centers (NFU): www.nfu.nl
About PLOS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases (http://www.plosntds.org/) is a peer-reviewed, open-access journal devoted to the pathology, epidemiology, prevention, treatment, and control of the neglected tropical diseases, as well as public policy relevant to this group of diseases. All works published in PLOS Neglected Tropical Diseases are open access, which means that everything is immediately and freely available subject only to the condition that the original authorship and source are properly attributed. The Public Library of Science uses the Creative Commons Attribution License, and copyright is retained by the authors.
About the Public Library of Science
The Public Library of Science (PLOS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 31-Jan-2013[ | E-mail |
Share ] Contact: Matthew Lopez
mlopez@plos.org
415-568-3174
Public Library of Science
Fight against river blindness is successful and inexpensive
A relatively inexpensive program set up to combat river blindness, an infectious disease, has resulted in major health improvements in Africa, shows a study conducted by Erasmus University Medical Center researchers. The study, due to be published January 31 in PLOS Neglected Tropical Diseases, shows that US$250 million helped cure or prevent blindness, skin disease, severe itching, and other symptoms in millions of people. In collaboration with the Management of the African Programme for Onchocerciasis Control (APOC), the researchers calculated the health impact of APOC.
Onchocerciasis, also known as river blindness, is an infectious parasitic disease transmitted by flies that live near fast-flowing rivers. The worm that causes the disease lives in subcutaneous nodules. The bite of the fly passes the worm's larvae from human to human. During their lifetime, people in endemic regions often contract several infections, which accumulate and can lead to blindness. Infected people may suffer from severe itching, leading to insomnia and inability to concentrate. This makes working or going to school difficult. 'This means people are less able to provide for themselves, especially in developing countries,' says Erasmus MC researcher Luc Coffeng. 'It is for a reason that in images of river blindness you often see a blind person moving around holding the end of a stick accompanied by a child holding the other end.'
In 1995, the WHO launched the African Programme for Onchocerciasis Control (APOC) to combat river blindness. APOC has geographically mapped the disease, and has started annual mass treatment with the drug ivermectin in sixteen African countries. Ivermectin kills the larvae in the human and thus prevents transmission of the infection and development of irreversible symptoms, such as blindness. Manufacturer Merck helps by providing ivermectin for as long as needed, free of charge. APOC distributes the drug in an efficient and inexpensive manner through a community-directed approach. Specially trained volunteers operate at the local level; they find out which people are eligible for treatment, and ensure that these people get the drug. This saves time for health professionals, and makes it easier to continue mass treatment in situations of political instability.
In fifteen years' time, APOC has had a major health impact at relatively low cost, according to the researchers. The percentage of people infected with the parasite decreased from 45 to 31 percent among a population of 104 million people. 'Blindness and visual impairment now occur much less frequently in the APOC countries. And the percentage of people suffering from severe itching decreased from 14 to 6 percent,' said Coffeng. The researchers express the impact of the programme in terms of years of healthy life gained: 'This metric expresses our preference for people to live their life in good health rather than in disease. For instance, for every year lived in blindness, we consider 0.6 years of healthy life lost.' The program has already saved a total of eight million healthy years of life, at a cost of about US$250 million. 'Peanuts compared to what we in the Western world are spending on healthcare,' commented Coffeng. 'APOC costs 30 dollars for every year of healthy life gained, while in the Western world we are willing to spend tens of thousands of dollars to achieve this.'
The fight against river blindness is not yet over. The percentage of people carrying infection is expected to decline further, to about 18% in 2015. 'APOC has made tremendous efforts to implement mass treatment in all countries in need. The last countries joined the program only in 2010. Treatment must continue for many years, because the drugs only kill the larvae and not the adult worms, which can live inside humans for over 10 years,' observes Coffeng. In other words: it is very important that APOC continues its activities, which requires continued support from drug-donating pharmaceutical companies and donor countries, and continued commitment from national governments of the African countries in question and local volunteers. 'The eventual goal of APOC is to completely eradicate river blindness, and this seems to be possible if all stakeholders commit to that goal.'
###
FINANCIAL DISCLOSURE: This study was funded by the World Health Organization / African Programme for Onchocerciasis Control (APOC/CEV/322/07). H.G.M. Zour, K.B. Agblewonu, M. Noma, G. Fobi, U.V. Amazigo are or have been employees of the African Programme for Onchocerciasis Control (APOC), World Health Organization. The authors state that their employment has not caused any conflict of interest in any of the following: study design, data collection, data analysis, interpretation, decision to publish.
COMPETING INTERESTS: The International Bank for Reconstruction and Development/World Bank serves as Fiscal Agent to WHO APOC through its fiduciary oversight of the APOC Trust Fund and contributed to this paper through its work with the APOC secretariat in the maintenance of accurate financial records. The findings, interpretations and conclusions expressed in this paper do not necessarily reflect the views of the World Bank. Furthermore, H.G.M. Zour, K.B. Agblewonu, M. Noma, G. Fobi, U.V. Amazigo are or have been employees of the African Programme for Onchocerciasis Control (APOC), World Health Organization. The authors state that their employment has not caused any conflict of interest in any of the following: study design, data collection, data analysis, interpretation, decision to publish.
CITATION: Coffeng LE, Stolk WA, Zoure HGM, Veerman JL, Agblewonu KB, et al. (2013) African Programme for Onchocerciasis Control 1995: Model-Estimated Health Impact and Cost. PLoS Negl Trop Dis 7(1): e2032. doi:10.1371/journal.pntd.0002032
CONTACT:
Luc Coffeng
l.coffeng@erasmusmc.nl
Disclaimer
This press release refers to an article in PLOS Neglected Tropical Diseases. The release is provided by the article authors. Any opinions expressed in these releases or articles are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLOS. PLOS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.
Media Permissions
PLOS Journals publish under a Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits free reuse of all materials published with the article, so long as the work is cited (e.g., Kaltenbach LS et al. (2007) Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration. PLoS Genet 3(5): e82. doi:10.1371/journal.pgen.0030082). No prior permission is required from the authors or publisher. For queries about the license, please contact the relative journal contact indicated here: http://www.plos.org/journals/embargopolicy.php
About Erasmus University Medical Center, Rotterdam
Erasmus MC is the largest and most authoritative scientific academic medical center in the Netherlands. Almost 13,000 staff members work within the core tasks of patient care, education, and scientific research on the continuous improvement and enforcement of individual patient care and social healthcare. They develop high-level knowledge, pass this on to future professionals, and apply it in everyday patient care. Over the next five years, Erasmus MC wants to grow into one of the best medical institutes in the world. Erasmus MC is part of the Dutch Federation of University Medical Centers (NFU): www.nfu.nl
About PLOS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases (http://www.plosntds.org/) is a peer-reviewed, open-access journal devoted to the pathology, epidemiology, prevention, treatment, and control of the neglected tropical diseases, as well as public policy relevant to this group of diseases. All works published in PLOS Neglected Tropical Diseases are open access, which means that everything is immediately and freely available subject only to the condition that the original authorship and source are properly attributed. The Public Library of Science uses the Creative Commons Attribution License, and copyright is retained by the authors.
About the Public Library of Science
The Public Library of Science (PLOS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/plos-apf012413.php
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